Sep. 1, 2009
New NSF Center Aims to Simplify Drug Synthesis
Emory chemist Huw Davies has received $1.5 million from the National Science Foundation to establish an NSF Center for Chemical Innovation. Davies will lead a team of scientists from four universities to develop the center, focused on stereoselective C-H functionalization.
“Our collaboration brings together world leaders in this field,” says Davies, professor of organic chemistry. “It’s exhilarating to have this chance to share ideas for moving C-H functionalization into more robust and practical applications, especially in regard to drug synthesis.”
One of the aims of the researchers will be to speed up and simplify the synthesis of new classes of pharmaceuticals, to make their production affordable and scalable.
“We want to develop more efficient ways of cooking,” Davies explains.
Creating a New Chemistry Lab
‘A paradigm shift’
Carbon-carbon (C-C) and carbon-hydrogen (C-H) bonds are generally the strongest bonds of an organic chemical, providing a stable framework for a molecule. For decades, the main strategy of organic chemistry was to leave these stable bonds alone, and focus on modifying more reactive bonds.
“C-H functionalization involves a paradigm shift,” Davies says. “We’re trying to modify the C-H bonds, while leaving alone the reactive groups. It can be tricky, but it has the possibility of giving you more flexibility for the type of structures you can access.”
The NSF Centers for Chemical Innovation program addresses major, long-term basic chemical research problems that have a high probability of both producing transformative research and leading to innovation.
Streamlined drug synthesis
Davies lab has done groundbreaking work in C-H functionalization, including developing methods of stereoselective methods, which control the three-dimensional shape of a molecule.
His lab focuses on streamlined synthesis methods for drug discovery and has garnered 10 patents, more than 180 peer-reviewed publications, ongoing funding from the National Institutes of Health and the NSF, and collaborations with scientists working on therapies for everything from cancer to drug addiction.
The American Chemical Society recently named Davies one of the inaugural class of ACS Fellows.
Center to grow in two phases
The team for phase I of the NSF Center in Chemical Innovation at Emory includes Simon Blakey, assistant professor of organic chemistry at Emory, and Jamal Musaev, director of Emory’s Cherry L. Emerson Center for Scientific Computation, in addition to chemists from Stanford, the University of Illinois at Urbana-Champaign and the Scripps Research Institute.
After three years, the center can apply to become a phase II center, and additional NSF funding of $20 million.