News Release: Emory Healthcare , Research , School of Medicine , Winship Cancer Institute

Apr. 5,  2011

Winship Cancer Institute Offers Clinical Trial for Rare Form of Lymphoma

News Article ImageWinship Cancer Institute

Atlanta - Emory’s Winship Cancer Institute has opened a clinical trial for treatment of a rare form of lymphoma called Waldenstrom’s Macroglobulinemia (WM) and is the only cancer facility in the state of Georgia where this treatment is available.  

WM is a slow-growing form of Non-Hodgkins Lymphoma, which affects a person’s immune system and produces a condition in which the blood contains high levels of proteins and becomes too thick to flow normally through small blood vessels. Symptoms include weakness, extreme fatigue, weight loss and bruises/bleeding or enlargement of lymph glands.   

There are only approximately 1,500 cases of WM diagnosed annually.  Median age at diagnosis is 63.   

The study provides the drug everolimus (RAD001) for previously untreated patients over age 18 with symptomatic Waldenstrom’s Macroglobulinemia.  RAD001 will be taken orally each day for 28days.  Responding patients may continue treatment for up to 48 months.   

In a previous phase II study of RAD001 given to 50 patients with symptomatic relapsed/refractory Waldenstrom’s Macroglobulinemia there was a 70% overall positive response rate. RAD001 has been used as an immunosuppressant in solid organ transplantation since 1996.  In addition, RAD001has been approved for treatment of advanced renal cell carcinoma.  

This trial is being conducted at Winship as part of a national, multi-institutional study done through the Waldenstrom Macroglobulinemia Clinical Trials Group.  More information is available at or through the National Cancer Institute at  Thomas Heffner, MD, associate professor of hematology and medical oncology at Winship, is the principal investigator.



The Robert W. Woodruff Health Sciences Center of Emory University is an academic health science and service center focused on missions of teaching, research, health care and public service.

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